The Moremi Game Reserve and its surrounding area is often the focal point for many safaris in the Okavango Delta. It includes habitats from both the permanently and seasonally flooded zones. With the exception of the eastern "tongue" of Moremi, access into the Okavango Delta is only by aircraft. Moremi covers almost a third of the entire Okavango Delta - a diverse habitat where the desert and water meet, comprising forests, lagoons, floodplains, pans and woodlands. It contains the full spectrum of game and bird life found in the Okavango and is the primary safari attraction in the Delta.

The Reserve covers the area at the eastern section of the Okavango Delta. Moremi has been described as one of the most beautiful wildlife reserves in Africa, with a great diversity of plant and animal life. It contains - within its boundaries - approximately 20% of the Delta, and a vast range of habitats, acacia forests, floodplains, reed beds, lagoons, enduring wetland through mopane forest and dry savanna woodland. The mainland part forms only about thirty percent of the reserve – the remaining area being part of the Okavango Delta.

The Moremi Game Reserve is at its best during the dry season and game viewing is at its peak from July to October, when seasonal pans dry up and the wildlife concentrates on the permanent water. At any time of the year, game is prolific. Birdlife is prolific and varied, ranging from water birds to shy forest dwellers. There are many species of ducks and geese, as well as an amazing variety of heron. The variety of other animals includes: elephant, buffalo, giraffe, antelope, as well as lion, leopard, cheetah, jackal, hyaena and wild dog. The wild dog, particularly, is a regular feature at Moremi, and have been subject to a project being run in the area since  1989 .